OVA-mRNA-LNP–treated mice displayed reduced airway resistance (Figure 2H), decreased eosinophilia (Figure 2I), diminished proportion of Th2 (GATA3+) cells, and increased IFN-γ+ CD4+ T cell frequency (Figure 2J), paralleling the acute response. This evidence concerns the gene CD4 and Increased total eosinophil count.