Gonadotropin releasing hormone (GnRH) leads to luteinizing hormone (LH) secretion, which further stimulates the ovarian theca cells to produce androgen.[39] The traditional theory suggests that ovarian theca cells are the main cell type that produces excess androgen during the process of PCOS.[5] However, whether hepatocytes are involved in androgen production remains largely unexplored. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.