KLF9 and polycystic ovary syndrome: Global AR knockout mice are resistant to androgen‐induced PCOS.[47] The AR antagonist flutamide could be used to alleviate symptoms of PCOS in some patients.[46] In the setting of PCOS, Klf9 liver‐specific knockout mice display alleviated PCOS symptoms, a finding that is in consistent with the phenotype of AR global knockout mice.