To explore the role of hepatic KLF9 in the development of PCOS in vivo, we generated a hepatocytes‐specific Klf9 knockout mouse model (Alb‐Cre+; Klf9fl/fl, hereafter referred to as LKO) by crossing mice carrying the floxed Klf9 allele [25] with mice expressing Cre recombinase under the control of the albumin promoter and enhancer, littermates lacking the Cre gene were used as controls (Alb‐Cre−; Klf9fl/fl, hereafter referred to as WT). The gene discussed is ALB; the disease is polycystic ovary syndrome.