This effect, primarily in PMN-MDSCs, restored and activated CD8+ T-cells through the downregulation of TIGIT (also called T-cell immunoreceptor, a surface protein that suppress T-cell activation [53] expression) and the upregulation of Granzyme B, both known to contribute to the ‘exhaustion’ state of infiltrating T-cells and in enabling CD8+ T-cells to eliminate cancer cells, respectively [49]. Here, CD8A is linked to cancer.