TSHR and neoplasm: TSHR has been found to be highly expressed in DTC through IHC and qPCR,[27, 28, 29, 30] more significantly, its expression was also detected in tumor tissues from metastatic and radioiodine‐resistant DTC patients.[29, 31, 32] Additionally, considering that the primary clinical approach for thyroid cancer involves surgical removal of the tumor and the normal thyroid,[33, 34] TSHR expression in normal thyroid tissue raises no concern for potential off‐tumor toxicity, as the normal thyroid has already been excised in patients.