Currently, most CAR‐T targets in solid tumors are tumor‐associated antigens, which are not exclusive to tumor tissue but are also found in normal tissues, such as MSLN, HER2, EGFR, and B7‐H3.[17, 18, 19, 20] Thus, when these tumors are targeted, the normal tissues expressing the corresponding antigens are inevitably affected. Here, MSLN is linked to neoplasm.