In the stratified analyses by age, sICAM‐1 was inversely associated with tumor budding among patients with later‐onset colorectal cancer (Table 3) (M1: β = −0.71, p‐value = 0.008, p‐interaction = 0.046; M2: β = −0.70, p‐value = 0.01, p‐interaction = 0.11), while IL‐8 (M2: β = 0.96, p‐value = 0.01, p‐interaction = 0.34) and sVCAM‐1 (M1: β = 1.48, p‐value = 0.04, p‐interaction = 0.02) showed positive associations with tumor budding count among early‐onset patients (Figure 2). The gene discussed is CXCL8; the disease is neoplasm.