In stratified analysis by sex (Table 4), we observed a positive association between CRP and tumor budding count among male patients (M1: β = 0.23, p‐value = 0.001, p‐interaction = 0.002; M2: β = 0.22, p‐value = 0.004, p‐interaction = 0.005), while a negative association was observed for sICAM‐1 among female patients (M1: β = −0.81, p‐value = 0.03, p‐interaction = 0.35). Here, CRP is linked to neoplasm.