Interactions between SRC‐1 and AP‐1, serum response factor, and NF‐κB have been reported in vitro.[27] SRC‐1 plays a role in tumor progression and metastasis by modulating the transcriptional activity of key genes.[28] Fundamentally, SRC‐1 serves as a major initiator of transcriptional networks, controlling effector genes and allowing cancer cells to evade treatment and ultimately metastasize to distant organs. The gene discussed is JUN; the disease is cancer.