CD274 and colorectal cancer: Recruitment of SRC‐1 to AP‐1, which interacts with the colony‐stimulating factor (CSF), attracts more macrophages to the tumor site.[29] Studies have indicated that SRC‐1 upregulates PD‐L1 expression, promoting immune escape of colorectal cancer cells in vitro and in vivo.[30] However, whether SRC‐1 interacts with specific transcription factors to regulate MMP12 expression has not been investigated.