In contrast with cytokine‐focused pathways, SRC‐1 directly co‐activates STAT1 to regulate MMP12 transcription, creating a feed‐forward loop where MMP12 cleavage of IFN‐γ further modulates STAT1 signaling.[17] This contrasts with the role of SRC‐1 in breast cancer metastasis via M‐CSF1[33] and TWIST [29], which highlights its context‐dependent functions. The gene discussed is MMP12; the disease is breast cancer.