In coculture experiments involving M1 macrophages and HUVECs, the levels of IL‐6, IL‐8, and CXCL10 were increased in the RA‐FME group compared with the OA‐FME group, with significant differences in the levels of IL‐6 (Figure 5B,C,E). This evidence concerns the gene IL6 and rheumatoid arthritis.