Integrated transcriptomic analyses of PBMCs from GVHD patients and healthy donors reveal downregulation of pro‐inflammatory and interferon‐gamma–signal transducer and activator of transcription 1 (IFN‐γ–STAT1)–associated genes, coinciding with the suppression of M1 macrophage signatures and induction of anti‐inflammatory profiles. Here, STAT1 is linked to graft versus host disease.