C]MPC‐6827 for early detection of MT dysfunction in AD using longitudinal PET imaging in transgenic mouse models, including amyloid precursor protein/presenilin 1 (APP/PS1), PS19 transgenic mice (P301S), and five familial AD (5xFAD) (Figure 4A), which exhibit early Aβ and tau pathology. This evidence concerns the gene PSEN1 and Alzheimer disease.