APC and Cachexia: In the preclinical Apc(min/+) mouse model, a min (multiple intestinal neoplasia) mutation in the APC gene causes mice to form neoplasia throughout the intestines beginning around 4 weeks of age, progressing to cachexia by 14 weeks of age, and finally to severe cachexia by 20–24 weeks of age [33, 34, 35].