IL4 and thyroid cancer: Spatial characterization identified SPP1hi‐Macro cell enrichment in PPTC microenvironments ‐ a myeloid subpopulation associated with therapeutic resistance in multiple malignancies.[35, 36] These M2‐polarized macrophages secreted protumorigenic cytokines (IL‐4, TGF‐β, IL‐10), establishing a feedforward loop that amplifies metastatic potential.[37, 38, 39] This mechanistic framework aligns with prior observations of BRAFV600E‐mediated myeloid recruitment in thyroid cancer progression,[40] suggesting convergent pathways in pediatric and adult disease evolution.