Inappropriate protein aggregation is a central molecular signature of chronic neurodegenerative diseases; in Motor Neuron disease (MND), 97% of cases are reported to develop insoluble deposits of TAR DNA‐binding protein 43 (TDP‐43).[1] TDP‐43 is a highly conserved protein predominantly located in the nucleus, where it plays an essential role in RNA transcription, splicing, and nucleocytoplasmic transport. Here, TARDBP is linked to mild neurocognitive disorder.