TARDBP and mild neurocognitive disorder: In MND‐affected neurons, TDP‐43 is sequestered in the cytoplasm by the accumulation of large insoluble aggregates decorated with aberrant post‐translational modifications.[2] Mutations in TDP‐43 are also a rare cause of MND, and some studies suggest that these variants increase the propensity of TDP‐43 to aggregate.[3] However, decades of research are yet to satisfactorily resolve the role of aggregates in disease pathology and progression.