We have successfully used this strategy to specifically and sensitively detect tau assemblies derived from Alzheimer's disease biofluids.[12] Applying the same logic, we selected an antibody (flTDP) that recognizes the 203‐209 residue region[16] of TDP‐43 capable of detecting full‐length and truncated TDP‐43 isoforms commonly associated with MND.[17]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.