Collectively, the different transcriptional dynamics in the repetitive BLEO‐IPF mouse suggest that senescent cells contribute differentially to sustain lung fibrosis, i.e. p21/p53‐dependent DNA damage responses play a significant role in the initiation phase, followed by a transition to p16‐driven maintenance of fibrosis (Janssen et al., 2024; Verleden et al., 2020). This evidence concerns the gene CDKN1A and pulmonary fibrosis.