Moreover, the single BLEO‐IPF mouse displayed similar gene expression changes to the human IPF dataset, with marked upregulation of inflammatory mediators (Il6, Ccl2), ECM components (Col1a1, Col3a1, Fn1, Loxl2, Mmp2), and TGF‐β pathway signaling (Tgfb1, Smad2) (Figure 5c). This evidence concerns the gene SMAD2 and idiopathic pulmonary fibrosis.