While our lung RNA sequencing analysis corroborated histological findings of fibrosis in the repetitive BLEO‐IPF mouse at the baseline time point, a subset of structural ECM components (Col1a1, Col3a1, Fn1, Loxl2, Mmp2) and TGF‐β signaling (Tgfb1, Smad2) were attenuated or resolved at the study week 8 time point. Here, SMAD2 is linked to idiopathic pulmonary fibrosis.