In accordance with clinical findings (Lin & Xu, 2020; Parimon et al., 2023), the repetitive BLEO‐IPF mouse model has been reported to exhibit significant upregulation of pulmonary SASP factors, including H2AX, transforming growth factor‐beta (TGF‐β), and various matrix metalloproteinases (MMPs), which can reinforce the fibrotic microenvironment (Degryse et al., 2010; Lv et al., 2022; Parimon et al., 2021; Schafer et al., 2017). Here, H2AX is linked to idiopathic pulmonary fibrosis.