Hence, developing multiple‐hit models by combining repetitive BLEO with an additional pro‐fibrotic insult induced by intratracheal administration of lipopolysaccharide (LPS), Adeno‐associated virus (AAV)‐mediated pulmonary overexpression of TGFβ1 or repetitive BLEO administration in transgenic mouse models of IPF (Kim et al., 2022; Kurniawan et al., 2023; Lawson et al., 2005; Strobel et al., 2022), may potentially offer models with enhanced features of progressive fibrosis and thus improved clinical translatability. This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.