The transcription factor Forkhead Box 1 (FOXS1) is an emerging biomarker in liver fibrosis [187], and it could be that it is essential for insulin resistance to initiate fibrotic pathways, as CRISPR FOXS1 knockout in human LX2 HSCs increased the kinase activity of the insulin receptor [187]. The gene discussed is INSR; the disease is Hepatic fibrosis.