Though upregulated expression of polymeric immunoglobulin receptor (PIGR) may indicate the polarized state of tumor-associated immune cells in BRCA (Asanprakit et al., 2022), differential expression of PIGR as a transporter of polymeric immunoglobulins across epithelial cells in BRCA cells may not necessarily impact cellular and cellular behaviors (Asanprakit et al., 2023). The gene discussed is PIGR; the disease is neoplasm.