Routinely available clinical variables (hypertension, CAD, AF, rales, peripheral oedema, JVD, heart rate, SBP), laboratory variables (haemoglobin, eGFR, BNP) as well as echocardiography variables (LVEF, LVMi, LAVi, LVEDVi, TAPSE, PASP, E/e′ lateral, and E/A ratio) were selected to conduct the clustering analysis herein. This evidence concerns the gene NPPB and Peripheral edema.