In comparison to other duplications and deletions in the same region, the minimal duplicated/deleted region is the 35 kb locus containing the CHD8 and SUPT16H genes, and this is consistent with the fact that variants within and deletion of this chromosomal interval also cause neurodevelopmental deficits such as developmental delay, intellectual disability with speech impairment, ASD, ADHD, and epilepsy [2,3]. Here, CHD8 is linked to Global developmental delay.