BRAF and superficial spreading melanoma: For instance, the B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutations are common in melanomas arising on intermittently sun-exposed skin (e.g., SSM), whereas KIT proto-oncogene receptor tyrosine kinase (KIT) and Neurofibromin 1 (NF1) mutations are more prevalent in acral and desmoplastic melanomas, respectively [10].