SSM: Superficial spreading melanoma; NM: Nodular melanoma; LMM: Lentigo maligna melanoma; ALM: Acral lentiginous melanoma; DM: Desmoplastic melanoma; MAPK: Mitogen-activated protein kinase; TMB: Tumor mutational burden; BRAF: B-Raf proto-oncogene, serine/threonine kinase; NRAS: Neuroblastoma RAS viral oncogene homolog; KIT: KIT Proto-oncogene receptor tyrosine kinase; NF1: Neurofibromin 1. The gene discussed is BRAF; the disease is nodular malignant melanoma.