PRKD1 is a serine/threonine kinase belonging to a family of calcium calmodulin kinases (PRKD) alongside two isomers (PRKD2 and PRKD3), playing a pivotal role in key regulatory mechanisms and physiological roles, including cell proliferation, survival, migration, angiogenesis, regulation of gene expression, and protein/membrane trafficking [17], which are intricately involved in pathological processes such as cardiac hypertrophy and cancer progression [18]. Here, MARK2 is linked to cardiac hypertrophy.