It also simultaneously activates the p‐STAT3/p‐GSK‐3β/p‐PYGL/p‐GYS2 axis in M2 MΦs, enhancing their mitochondrial metabolism and energy supply from glycogen particles, thereby inducing them to excrete cholesterol into the plaques and resist ASCVD. The gene discussed is STAT3; the disease is atherosclerosis.