While both National Institute on Aging and Alzheimer's Association (NIA‐AA) (Petersen et al. 2021) and International Working Group (IWG) criteria (Dubois et al. 2021) acknowledge β‐amyloid and tau deposition as neuropathogenic hallmarks of AD, there is a fundamental disagreement on their relevance in cognitively unimpaired individuals. Here, MAPT is linked to Alzheimer disease.