Viral components activating innate cells through pattern recognition receptors, such as Toll-like receptors, retinoic-acid-inducible gene I and melanoma differentiation-associated gene 5, are vital in eliciting a downstream signalling cascade, which culminates in the secretion of inflammatory proteins.<h4>Conclusion</h4>Understanding the specific mechanisms involved in the acute phase of infection is indispensable for detecting differential biomarkers against flavivirus infections as well as designing more efficient therapeutic agents and vaccines. Here, RIGI is linked to infection.