Specifically, in hepatocellular carcinoma, DNMT2 promotes tumour progression and enhances bortezomib resistance by repressing the pro‐apoptotic gene TNFSF10 [27]; in colorectal cancer, a TRDMT1‐regulated tRNA fragment tRF‐3022b modulates apoptosis and M2 macrophage polarisation [28]. Here, TRDMT1 is linked to hepatocellular carcinoma.