Specifically, in hepatocellular carcinoma, DNMT2 promotes tumour progression and enhances bortezomib resistance by repressing the pro‐apoptotic gene TNFSF10 [27]; in colorectal cancer, a TRDMT1‐regulated tRNA fragment tRF‐3022b modulates apoptosis and M2 macrophage polarisation [28]. The gene discussed is TRDMT1; the disease is colorectal cancer.