For example, in EGFR-mutant lung adenocarcinoma cells, metformin inhibits mitochondrial electron transport complex 1 to induce AMPK activation, leading to the inhibition of the mTOR pathway, which causes G0/G1 cell cycle arrest, mitochondrial apoptosis, and reduction of tumor growth [60, 61]. The gene discussed is EGFR; the disease is lung adenocarcinoma.