Fasting blood glucose levels were lower after long-term high-fat diet challenge only in mice lacking both STK25 and MST3, while plasma insulin concentrations and HOMA of insulin resistance (HOMA-IR) values were down-regulated in all groups depleted of STK25, MST3, or STK25/MST3 compared with their respective controls (Fig. 1F–H). The gene discussed is INS; the disease is Insulin resistance.