Importantly, since obese Stk25–/– and Mst3–/– mice showed improved insulin sensitivity in the absence of significant decreases in body weight and fat mass, it is likely that the protection against high-fat diet-induced insulin resistance observed in STK25/MST3-deficient mice is also mediated by metabolic adaptations beyond just reduction in body and fat mass gain. This evidence concerns the gene STK25 and Insulin resistance.