PTCH1 and rhabdomyosarcoma: A role for aberrant Hh signalling in sarcomagenesis was first realised in patients with Gorlin’s syndrome, caused by inactivation of the PTCH1 or SUFU genes, who are predisposed to the development of basal cell carcinomas, medulloblastoma, fibrosarcoma and rhabdomyosarcoma [96–98].