SMARCB1 and neoplasm: However, in some cases, the genomic driver can be a different event, such as in malignant rhabdoid tumours which are exclusively driven by biallelic inactivation of the tumour suppressor genes SWI/SNF related Matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) or less frequently SMARCA4, both of which encode critical subunits of the Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodelling complex that regulate large sets of genes required for key developmental processes [36].