TAFAZZIN and Barth syndrome: Three mouse models have been developed for BTHS, including Tafazzin-KD (Suzuki-Hatano et al, 2019; Acehan et al, 2011; Soustek et al, 2011; Phoon et al, 2012; Greenwell et al, 2021), Tafazzin knock-out (Tafazzin-KO) (Zhu et al, 2021; Liu et al, 2021; Tomczewski et al, 2023), and very recently, a mouse model that expresses a specific patient variant (G197V) through targeted knock-in (Tafazzin-KI) (Chowdhury et al, 2023) (Table 2).