Along the same line, DCM-associated R9C PLN variant was linked to a metabolic shift in hiPSC-CMs from aerobic to anaerobic metabolism (Ceholski et al, 2018), and small molecule kinase inhibitors were able to rescue the DCM phenotype in hiPSC-CM, thereby improving contractility and metabolic function (Perea-Gil et al, 2022). The gene discussed is PLN; the disease is familial dilated cardiomyopathy.