NR3C2 and perinatal asphyxia: On the other hand, glucocorticoids may act as adjuvant therapy to hypothermia, because they can modulate apoptosis and inflammatory response to the hypoxic injury in the neonatal brain, and optimize neuroplasticity via glucocorticoid and mineralocorticoid receptor pathways based on animal hypoxic-ischemic encephalopathy models [23, 24].