Although numbers of patients of each CTAP are small (n = 3 CTAP:T + F, n = 5 all other CTAP) there is a clear trend showing increased expression of collagens 1, 3 and 6, but not COL14, in lining fibroblasts of RA patients with a CTAP:M phenotype, and COL6A1 was significantly upregulated between RA CTAP:M and OA patients (Appendix Fig. S7M). Here, COL6A1 is linked to rheumatoid arthritis.