MMP2 and rheumatoid arthritis: Paired proteomic and degradomic analysis however reveal further complexity that dictates tissue COL6 expression; with higher myeloid-dependent, MMP2/9-mediated COL6 degradation in RA compared to OA, leading to the generation of disease-specific fragment fingerprints, a finding corroborated by the detection of COL6 degradation products in the serum of people with RA that are regulated during treatment (Thudium et al, 2024).