Ablation of other constituents of PANoptosis, including ZBP1, RIPK3, Caspase-6, and the NLRP3 inflammasome, fails to yield a better prognosis in IAV-infected mice.5,7,11–16 This reflects the dilemma of optimally regulating the cell death process to eliminate infections while preventing uncontrolled inflammation. The gene discussed is ZBP1; the disease is infection.