Actually, NINJ1 has already been reported to be a mediator of PANoptosis induced by comorbid heat stress and infection.24 In that model, ablation of NINJ1 rescued BMDMs from cell death and did not impair the inflammasome-dependent release of IL-1β and IL-18.24 Although IAV infection and heatstroke are similar in that PANoptosis induced by both are initiated by ZBP1,25 it is unknown whether NINJ1 functions similarly during IAV infection. Here, IL1B is linked to infection.