Novel biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), and the combined urinary assay of tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7 (TIMP-2·IGFBP7) have emerged as promising tools for early AKI detection. The gene discussed is TIMP2; the disease is acute kidney injury.