By 2021, the age-standardized death rate had decreased for G6PD to 17.49 (95% UI 10.90 – 30.61), or was fairly consistent for SCD 0.52 deaths (95% UI 0.31 – 0.96) and thalassemias caused 0.21 (95% UI 0.14 – 0.30), per 100,000 population compared to 2000. The gene discussed is G6PD; the disease is thalassemia.