Although AIM2 inflammasome activation is induced by viral DNA and mtDNA during herpesviruses infection, it is inhibited by different viral proteins, including HSV-1 VP22 [22], HCMV pUL83 [34], MCMV M84 [35] and KSHV SOX [23], which evade AIM2-related antiviral responses and pyroptosis to ensure effective viral infection and propagation. The gene discussed is AIM2; the disease is viral infectious disease.