DYRK1A and cystic fibrosis: Here we took advantage of Tg(Dyrk1a) - a model with 3 copies of Dyrk1a [50] - and compared with the results of the new model Dp(16)13Yah where Dyrk1a is not overexpressed, to confirm the role of Dyrk1a in the development of the DS CF phenotype.