Here we took advantage of Tg(Dyrk1a) - a model with 3 copies of Dyrk1a [50] - and compared with the results of the new model Dp(16)13Yah where Dyrk1a is not overexpressed, to confirm the role of Dyrk1a in the development of the DS CF phenotype. Here, DYRK1A is linked to Dravet syndrome.