CDKN1C and type 2 diabetes mellitus: High-scoring βT2D-DEGAS cells had elevated expression of CDKN1C (p57Kip2) which binds and inhibits G1 cyclin/CDK complexes and is also involved in cellular senescence (Stampone et al., 2018; Ou et al., 2019), and reduced expression of IAPP, consistent with results from bulk T2D islet expression data (Figure 1G).