Other work has shown that suppression of CDKN1C expression in hyperglycemic, immunodeficient mice increased β-cell replication by threefold and those newly replicated cells retained mature β-cell functionality, indicating that manipulating CDKN1C expression can cause B-cell expansion in T2D patients (Avrahami et al., 2014). The gene discussed is CDKN1C; the disease is type 2 diabetes mellitus.