An MTT assay was performed to test the cell viabilities of Dox‐treated HCC cells, and the results showed that after transfection with CAPG shRNA lentiviruses for 24, 48, 72 and 96 h, the cell viability of HepG2/Dox cells and Hep3B cells of shCAPG groups was significantly decreased compared with that of control shRNA groups (**p < 0.01, Figure 3A,B). This evidence concerns the gene CAPG and hepatocellular carcinoma.