BCL2 and acute myeloid leukemia: In specific AML cell models, such as MOLM-13 (FLT3-ITD mutated cell line) and Kasumi-1 (KITN822K mutated cell line), both inhibitors reduced phosphorylation of key proteins (S6RP [S6 ribosomal protein] and 4EBP1 [eukaryotic initiation factor 4E-binding protein 1]) and induced apoptosis, but NSC305787 was more effective in modulating genes related to the cell cycle and apoptosis, including CCNA2, BCL2, CDKN1A, and BAX [77].