Interestingly, we found that two of the 11 patients with uterine endometrioid carcinomas had alterations in ESR1, including two hotspot mutations at Tyr537 (Y537C and Y537N) and an alteration at Leu536 (L536R; Supplementary Fig. S2). The gene discussed is ESR1; the disease is endometrial endometrioid adenocarcinoma.