Germline STK11 inactivating mutations have been associated with Peutz–Jeghers syndrome (52), and somatic changes in this gene have been reported in a variety of cancers, including non–small cell lung cancer, cervical cancer, colorectal cancer, melanoma, and pancreatic cancer with predominantly truncating mutations but have not yet been reported in endometrioid ovarian carcinoma. This evidence concerns the gene STK11 and melanoma.