Consistent with these findings, there was evidence of muscle fiber regeneration in gastrocnemius muscles of both Apoc3+/+ and Apoc3−/− mice in response to ischemia, as measured by the increased percentage of muscle fibers with centralized nuclei compared to the non‐ischemic limb (p < 0.01; Figure 4C,D). Here, APOC3 is linked to ischemia.