upregulated in non-lesional skin and in psoriatic keratinocytesdownregulated in psoriatic serum, along with its interactors G1P3 and NPM-1high PRINS expression in the buccal epithelium with low expression in psoriatic keratinocytes lead to severe psoriasis with prolonged exacerbation and unfavorable prognosis. This evidence concerns the gene IFI6 and psoriasis.