Conversely, miR-222 appears to be upregulated in ZAP-70+ CLL, where it targets PTEN and p27Kip1, facilitating activation of the PI3K/AKT pathway and reducing apoptosis, consistent with the enhanced survival signaling driven by ZAP-70 [82]; miR-150 is expressed at lower levels in ZAP-70+ cases, leading to increased expression of FOXP1 and GAB1 [key enhancers of B-cell receptor (BCR) signaling]. This evidence concerns the gene BCR and B-cell chronic lymphocytic leukemia.