CXCR4 and acute myeloid leukemia: More specifically, AML exosomes present RNAs whose transcripts are implicated in AML pathogenesis, prognosis (NPM1, FLT3-ITD), response to therapy (CXCR4, IGFIR), and leukemic niche formation (IGF-IR, CXCR4, MMP9) [145].