DNM1L and neoplasm: Pb affects mitochondrial dynamics by altering expression of proteins including MFF (Mitochondrial fission factor controlling the division of mitochondria), Drp1 (dynamin-related protein 1, tightly regulated to clear the damaged mitochondria), MFN1 (mitofusin, functions as a tumor suppressor gene, activating the fusion process to depress the metastasis and invasion in vitro and in vivo), MFN2, and OPA1 (crucial regulators of the mitochondrial dynamics), increasing fission factors while decreasing fusion factors [152].