The involvement in the CLE assembly of eLOX-3 and 12R-LOX [4] (enzymes, respectively, encoded by the ALOXE3 and ALOX12B genes) was considered because mutations within these genes are associated with the Non-bullous Congenital Ichthyosiform Erythroderma (NCIE) [7]. Here, ALOX12B is linked to congenital non-bullous ichthyosiform erythroderma.