Other proteins in this network associated with ECM include TIMP3, A Disintegrin and Metalloproteinase 10 (ADAM10), Collagen Type V Alpha-1 (COL5A1), Collagen Beta(1-O)Galactosyltransferase 1 (COLGALT1) and Laminin Subunit Gamma-1 (LAMC1), of which ADAM10, COL5A1 and TIMP3 have been associated with aneurysm formation [30,31,41,42]. The gene discussed is COL5A1; the disease is aneurysm.