PNPLA3 and fatty liver disease: We found significant associations of the PNPLA3 rs738409 G allele (92.3%) and GG genotype (69.2%) with cirrhosis among MASLD patients (p = 0.021 and p = 0.008, respectively), reinforcing the established role of PNPLA3 in hepatic steatosis and fibrosis progression [9,33].