Complementing these findings, machine learning and molecular docking approaches have been employed to characterize pollutant-associated periodontitis, revealing key genes such as CXCL12, CYP24A1, and HMGCR as central mediators in IL-17 and TNF pathways and highlighting the diagnostic potential of integrative toxicogenomic models [41]. The gene discussed is CXCL12; the disease is periodontitis.