Likewise, cross-disease transcriptomic profiling has revealed crosstalk genes like TAGLN, MMP9, and TNFAIP6, which not only stratify disease subtypes but also serve as shared biomarkers for comorbidities such as systemic lupus erythematosus, reinforcing the predictive value of network-based classifiers [42]. This evidence concerns the gene MMP9 and systemic lupus erythematosus.