TGFB1 and thoracic aortic aneurysm: The genetic architecture of thoracic aortic aneurysms and dissections (TAAD) is far more diverse than previously recognized, spanning classical syndromic genes, genes governing extracellular matrix integrity and TGF-β signaling, cytoskeletal and junctional stability, proteoglycan biology, transcriptional regulation, and emerging functional candidates.