In obese patients, gene-expression analyses of adipose tissue showed that RAGE and Diaph1 transcripts are co-regulated: In subcutaneous fat, Ager expression positively correlates with Diaph1 levels (and with the detoxifying enzyme GLO1), and this RAGE-axis signature correlates strongly with local inflammation, adipocyte dysfunction, and systemic insulin resistance (HOMA-IR). This evidence concerns the gene DIAPH1 and Insulin resistance.