INS and obesity due to melanocortin 4 receptor deficiency: After analysis of pooled methylation changes within all time frames, seven pathways forkhead box O (FoxO), Toll-like receptor, mammalian target of rapamycin (mTOR), cyclic AMP (cAMP), phosphatidylinositol 3-kinase/protein kinase B (PI3K-Akt), insulin and adipocytokine] and associated CpG sites within genes linked with obesity or comorbidities development were highlighted (Figure 5).