Inherited thrombophilia, characterized by a genetic predisposition to venous thromboembolism (VTE), includes deficiencies of natural anticoagulants such as protein S, protein C, and antithrombin, as well as gain-of-function mutations like Factor V Leiden and the prothrombin G20210A variant [3]. The gene discussed is PROS1; the disease is Rare hereditary thrombophilia.